Title: The Relation of Methylenetetrahydrofolate Reductase Gene Mutation and Cystathionine β-synthase Gene Mutation Exist in Cerebral Infarction
Abstract: Objective: To explore the significance of gene mutation of methylenetetrahydrofolate reduc-tase(MTHFR C 667 T) and cystathionine β-synthase(CBS 844ins 68) in cerebral infarction. Methods: By polymerase chair reactio(PCR) or polymerase chair reaction and resriction fragment length polymorphism (PCR-RFLP), CBS 844ins 68 mutation and MTHFR C 667 T mutation were detected in 69 patients with cerebral infarction and 67 healthy controls. Results: There were no significant differences in the frequencies of MTHFR C 667 T and CBS 844ins 68 mutations between the patients and control groups. Conclusion: No significant difference of the frequency of MTHFR C 667 T and CBS 844ins 68 mutations between the patients and control subjects was found in this population, MTHFR and CBS polymorphism may not be associated with risk of cerebral infarction.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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Cited By Count: 2
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