Title: Genetic Mutations of Homocysteine Metabolism Related Enzymes in Patients with Ischemic Stroke
Abstract: To study genetic mutations of methylenetetrahydrofolate reductase (MTHFR) C677T and cystathionine-β-
synthasc (CBS) T833C related to homocysteine metabolism in patients with ischemic stroke, the MTHFR gene
C677T gene mutation and the CBS T833C gene mutation were detected by PCR-RFLP or ARMS method in 74 pa-
tients with ischemic stroke and 83 normal people for control. Results showed that the frequencies of MTHFR geneT
homogenetic type (2.7% ) , heterogenetic type (51.4% ) and T allele (28.4% ) in ischemic group were higher than
those in control group (1.2%, 39. 8% and 21.1%, respectively). The frequencies of CBS gene C homogenetic type
(13.5%) and C allele (43.9%) in ischemic group were higher than those in control group (6.0% and 38. 0%, re-
spectively). Multiple Logistic Regression analysis showed that together with the T allele in MTHFR, the C allele in
CBS and age were related to ischemic stroke (P0.05). The odds ratios (OR) of the T allele in MTHFR C677T
and the C allele in CBS T833C were 1.74 (95% CI 1.06-2.86) and 1.73 (95% CI 1.07-2.81 ) respectively. The
study revealed that the genetic mutations of MTHFR C677T, CBS T833C, were related with the ischemic stroke.
The genetic mutations of MTHFR C677T and CBS T833C may be genetic factors for ischemic stroke.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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