Title: A clinical study of concurrent chemoradiotherapy with 3D-CRT late-course hyperfractionated accelerated radiation therapy plus the DF project induction for intermediate and advanced esophageal carcinoma
Abstract: Objective To evaluate the clinical effects of concurrent chemoradiotherapy with 3D-CRT late-course hyperfractionated accelerated radiation therapy(LCAHF) plus the prognostic factors(PF) project induction on intermediate and advanced esophageal carcinoma.Methods 65 patients pathologically confirmed as having intermediate or advanced esophageal carcinoma were randomly allocated into two groups(33 in radiotherapy group and 32 in complex or chemoradiotherapy group).All patients were given external beam radiation of 6/15 MV X-ray.During the first two-thirds of the course,the patients received a routine dose of 1.8 Gy per fraction,five times per week,at a dosage of 40 Gy in both groups.For the one-thid that followed,LCAHF was given at a dose of 1.5 Gy,twice daily,at an interval of more than 6 hours,with the total dosage of 70 Gy.In complex group,chemotherapy regimen was combined with DF project.At the end of treatment,the efficiency,respective survival rates of 1,2 and 3 years,toxicity as well as side effects between the two groups were compared,based on Guidelines for Diagnosis and Treatment of Esophageal Carcinomas.Results In the radiotherapy group,CR was 36.4% and PR was 54.5%,and in the complex group,CR was 43.8% and PR was 53.1%,respectively.The 1-,2-,3-year survival rates were 39.4%,30.3%,24.2% in the radiotherapy group and 68.8%,56.3%,50.0% in the complex group,respectively(P0.05).The difference between the regional toxicity and side effects in the two groups were not statistically significant(P0.05),while in the complex group,the regional toxicity and side effects were higher than in the radiotherapy group(P0.05).Conclusions 3D-CRT with LCAHF plus PF project chemotherapy can remarkably promote the 1-2-3-year survival rates of intermediate and advanced esophageal carcinoma patients without increasing regional toxicity and side effects and is was worthy of clinical generalization.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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