Title: Prospective Trial for Concurrent Chemoradiotherapy Treatment in Medium-term and Advanced Cervical Carcinoma
Abstract: Objective To investigate the clinical curative effects and side effects of chemoradiotherapy for medium-term and advanced cervical carcinoma. Methods Fifty-eight patients of medium-term and advanced cervical carcinoma were randomly divided into two groups: chemoradiotherapy groups and only radiotherapy group. Each patients of the chemoradiotherapy group was given cisplatin at the dose of 25 mg/m2 ivgtt d1-3 ,5-Fluorouracil,350mg/m2 ivgtt,d1-5, repeat every 28 days, total 3 cycles. And radiotherapy was give at the same time, 10 MVX ray was used for external radiation with a total dose of 38~40 Gy;then the middle field is shielded by plumbum, continuous radiotherapy to total dose of 50~55 Gy; 192Ir high-dose-rate after loading unit was used for branchytherapy after 3 weeks of external radiotherapy at the dose in A point of 6 Gy per time for total 6~7 times. The patients of radiotherapy group were only received radiotherapy with the same dose and same methods. Results The effect rates of the chemoradiotherapy group and radiotherapy group were 96.6% and 86.2% respectively at the end of the radiotherapy with no difference significantly (P0.05); Three months after radiotherapy the effect rates in both groups were 96.6% and 65.5%,showing a significant difference (P0.05). The overall 3-year,5-year survival rates for the patients in chemoradiotherapy group and radiotherapy group were 79.3%,68.9% and 62.1%,51.7% respectively,P0.05. Disease-free survival rates were 62.1% and 41.4% respectively, P0.05. Pelvic recurrence rates were 31.0% and 17.2% respectively P0.05. More serious side effects were found in the chemoradiotherapy group. Especially in bone marrow inhibition and reaction of digestive tract, Which could be alleviated. Conclusion Concurrent chemotherapy and radiotherapy in medium-term and advanced cervical carcinoma can increase treatment effect and raise the survival of the patients ,obviously improve the short-term curative effect. Toxicity of patients was increasing but the patients could tolerate.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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