Title: Expression of Bcl-2,Bax in non-small cell lung cancer and MVD correlations research
Abstract: Objective:To explore the expressions difference of Bcl-2 and Bax factors in non-small cell lung cancer(NSCLC) and normal lung tissues by means of micro vessel density(MVD) symbol.Trace the two factors different expression during carcinogenesis and progression of lung cancer.Methods: To explore expressions difference of Bcl-2 and Bax in 63 cases with pathologically diagnosed NSCLC and 31 cases with normal lung tissues.Immunohistochemical technique and MVD count were employed.Results: Negative correlations were observed between Bcl-2 and Bax.The positive rate of Bcl-2 and Bax expression were significant in the high,middle and low differentiation of NSCLC,and so be the TNM staging of lung cancer Bcl-2(P0.05),but insignificant in gender and survival period.The positive rate of MVD were significant in the high,middle and low differentiation of NSCLC,and so be the TNM staging of lung cancer(P0.05),but insignificant in gender,smoking experience and tissues type.Conclusion: MVD has higher expression with Bcl-2 and Bax at early stage.But Bcl-2 will be passivated as cancer tissues diffusion.The method shows a new molecular targeted therapy with Bcl-2/Bax molecule for lung cancer at early stage.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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