Title: Study of the protective effect of salvia miltiorrhiza ennoblement for enteral nutrition on intestinal mucosa in MODS model rats
Abstract: Objective:To explore the protective effect of salvia miltiorrhiza for enteral nutrition in S-MODS model rats.Methods: 70 Wistar rats were randomly divided into four groups: control group(n=10),model group(n=20),nutrition fibre group(n=20) and salvia miltiorrhiza for enteral nutrition group(n=20).The experiment period was 12 days.At the end of experiment,blood routine,biochemistry index(ALB,AST,ALT,BUN,Cr,CK and CK-MB),the concentrations of IL-6,TNF-α and IL-1β were measured. Results: The model was successful by clinical manifestation,blood routine and pathology.The clinical symptom was improved,blood routine and pathology damage were relieved in salvia miltiorrhiza group.The concentrations of IL-6,TNF-α and IL-1 in salvia miltiorrhiza group were lower than model group and nutrition fibre group(P0.05).Conclusions: Salvia miltiorrhiza for enteral nutrition could prevent gut function damage,protect intestinal mucosa and decrease the concentrations of pro-inflammatory cytokines.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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