Title: The trends and significance of changes of nitric oxide in myocardial stunning caused by the recurrent reversible myocardial ischemia-reperfusion
Abstract: Objective To observe the relationship between the level of NO detected by ESR in the blood and the myocardial stunning caused by the recurrent, reversible myocardial ischemia-reperfusion injury(MIRI).Methods Fifteen New Zealand white rabbits were randomly divided into three groups: (1) control group,n=5;(2) L-Arg group,n=5;(3) L-NNA(L-nitro-arginine) group,n=5. The rabbits were anesthetized with intravenous pentobarbital. A suture ligature was passed around the left anterior descending coronary artery(LAD), so the artery could be occluded and reperfused. The LAD was occluded for 10 min three times and the first and second occlusions were followed by 10 min of reflow. After the third occlusion, the reperfusion was 120 min.Results In all groups,dP/dt max began to decrease at 5 min after the first ischemia.Compared with control group at 5 min after first reperfusion,NO level in L-Arg group was elevated significantly,P 0.05;while in L-NNA group,NO decreased significantly,P0.01.In comparison with the control group, dP/dt max in L-Arg group decreased significantly,P0.05;while in L-NNA group,dP/dt max improved significantly,P0.05.Conclusions The fact that NO level was elevated suggest that NO has a harmful effect on myocardial stunning at the early stage.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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