Title: Effect of Lidocaine on Acute Regional Myocardial Ischemia and Reperfusion in the Cat
Abstract: Wendland MF, Saeed M, Kondo C, Derugin N, Higgins CB. Effect of lidocaine on acute regional myocardial ischemia and reperfusion in the cat: an in vivo 31P magnetic resonance spectroscopy study. Invest Radiol 1993;28:61SM>28. RATIONALE AND OBJECTIVES. The authors examined the relationship between myocardial infarction, high-energy phosphate compounds, and regional contractility after myocardial ischemia and reperfusion in cats. METHODS. Hemodynamic measurements, high-energy phosphate levels, and segmental shortening were measured every 30 minutes in two groups of cats subjected to 2 hours of occlusion of the left anterior descending coronary artery and 4 hours reperfusion. Group 1 (n. = 10) animals were infused with a low level of lidocaine, 0.05 mg/kg/hr, while group 2 (n=10) received a higher dose, 7.5 mg/kg/hr. The infarcted region was measured postmortem. RESULTS. Group 1 animals had larger infarcts (39 ± 6 vs. 12 ±5% of jeopardy, P<.05) and less phosphocreatine recovery during reflow (52 ± 1% vs. 73 ± 1% of control, P<.01) than did group 2. Group 2 showed recovery of percentage systolic shortening during reflow (1.4 ± 1% at 30 minutes vs. 7.1 ± 2.3% at 4 hours, P<.05), whereas group 1 exhibited no improvement. A significant correlation was found between infarct size under the surface coil and phosphocreatine content during reflow, but not between contractile function and infarction size or metabolite levels during reflow. CONCLUSIONS. Lidocaine infusion enhanced recovery of myocardial contractility during reperfusion and decreased infarct size. Greater recovery of phosphocreatine during reperfusion was predictive of greater myocardial salvage during reperfusion.
Publication Year: 1993
Publication Date: 1993-07-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 5
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