Title: Effects of pretreatment with fentanyl on myocardial infarction size and cardiac function in rabbits with acute myocardial ischemia reperfusion injury
Abstract: Objective To study the myocardial protective effect of pretreatment with fentanyl on rabbits with acute myocardial ischemia reperfusion injury.Methods Twenty-four male New Zealand White rabbits were randomly divided into 3 groups:group C ( acute myocardial ischemia reperfusion injury group),group F ( fentanyl group) and group N-F ( naloxone-fentanyl group),with 8 cases in each group.All rabbits experienced 30 min of regional ischemia through the occlusion of the left anterior descending coronary artery( LAD),followed by 120 min of reperfusion.The rabbits in C group were only subjected to the above ischemia/reperfusion (I/R) sequence.The rabbits in Group F were intravenously injected with fentany1 0.15 mg/kg at 15 minutes before the coronary occlusion.The rabbits in Group N-F were intravenously injected with naloxone 3 mg/kg,followed by 70 μg/(kg · min) infusion before reperfusion and were intravenously injected with fentanyl 0.15 mg/kg at 15 min before myocardial ischemia.Heart rate(HR),left ventricular systolic pressure( LVSP),left ventricular end diastolic pressure( LVEDP),maximum positive and minimum negative left ventricular pressure derivatives ( + dp/dt and-dp/dt) were continuously monitored and recorded at baseline ( T0 ),30 min after ischemia( T1 ),and 10 min ( T2 ),30 min(T3 ),120 min(T4) after reperfusion during I/R process.After 120 min reperfusion,hearts were removed for the measurement of myocardial ischemia and infarction size.Results Compared with the baseline(T0),LVSP,± dp/dt decreased whereas LVEDP increased significantly during T1-T4 (P <0.05 ).There were no significant differences in homodynamic parameters between group C and group N F ( P > 0.05 ).In F group,the LVSP and + dp/dt were significantly higher than those of group C and group N-F after 30 min in reperfusion ( P < 0.05 ) and the infarction size and weight were smaller (P <0.01 ).Conclusions Pretreatment with fentanyl has protective effect against ischemia/reperfusion injury by limiting infarction size effectively and improving cardiac function.
Key words:
Ischemia-reperfusion injury; Fentanyl; Pretreatment; Cardiac function; Rabbit
Publication Year: 2012
Publication Date: 2012-04-25
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot