Title: Correlation between hyperuricemia and coronary heart disease or hypertension
Abstract: Objective To study the relationship between serum uric acid(UA) and coronary heart disease as well as hypertension,and to explore the clinical significance of hyperuricemia and the interaction of the risk factors of cardiovascular diseases such as hyperlipemia,diabetes,etc.Methods The levels of serum UA,total cholesterol(TC),triglyeride(TG) and glucose(GLU) were measured by HITACHI 7080 automatic biochemistry analyzer in 213 patients with coronary heart disease and hypertension(75 coronary heart disease,67 hypertension,71 coronary heart disease concomitant hypertension) and 100 healthy subjects.Results Patients with coronary heart disease or hypertension or coronary heart disease concomitant hypertension had strongly higher concentration of UA compared to that of controls(P 0.01) The levels of UA were(385.4 ± 95.3) μmol/L for coronary heart disease,(359.6 ± 86.2) μmol/L for hypertension and(391.5 ± 93.6) μmol/L for coronary heart disease concomitant hypertension,respectively.The ratios of hyperuricemia concomitant hypercholesteremia(39.73%),hypertriglyceridemia(52.05%) and diabetes(47.75%) were significantly elevated than those of non-hyperuricemia concomitant hypercholesteremia(20.42%),hypertriglyceridemia(15.42%) and diabetes(21.25%)(P 0.001).Conclusion There is a close correlation between hyperuricemia and coronary heart disease or hypertension.The interactions of hyperuricemia with hypercholesteremia,hypertriglyceridemia and diabetes would promote the occurrence and development of cardiovascular diseases.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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