Title: Role of Ultrasound Contrast Time-intensity Curves in Hepatic Tumor Characterization and the Evaluation of Radiofrequency Ablation Effect
Abstract: Purpose To explore the value of ultrasound contrast time-intensity curves in hepatic tumor qualitative diagnosis and evaluation of tumor ablation effect. Materials and Methods Forty-two patients who were clinically diagnosed as hepatic cancer or cirrhosis underwent contrast enhanced ultrasound for the tumor lesions within the liver, dynamic analysis of the lesions were executed with software SonoLiver CAP, the nature of the tumors were determined and the results were compared with those of the enhanced MRI. Ultrasound guided biopsy was followed with radiofrequency ablation treatment, two-dimensional and contrast enhanced ultrasound were executed two weeks after the ablation, and the results were compared with enhanced MRI findings during corresponding period. Results 52 tumor nodules were found with two-dimensional and color Doppler ultrasound, 65(33 hyperplastic nodules, 32 malignant lesions) with CEUS, 65(21 hyperplastic nodules, 44 malignant lesions) with ultrasound contrast timeintensity curves, and 61(20 hyperplastic nodules, 41malignant lesions) with contrast enhanced MRI; pathological examination revealed that 26 of the lesions were benign and 39 were malignant; there was statistically signifcant difference(χ2=4.561, P0.05)between the results of ultrasound contrast time-intensity curves and simple contrast enhanced ultrasound for the assessment of the nature of tumor; no statistically signifcant difference(χ2=0.003, P0.05) was found between ultrasound contrast time-intensity curves and enhanced MRI for the assessment of the nature of tumor; there was statistically significant difference(χ2=5.298, P0.05) between ultrasound contrast time-intensity curves and simple contrast enhanced ultrasound for the assessment of whether the tumor was malignant or benign, when taking biopsy results as the reference standard. Conclusion With ultrasound contrast time-intensity curves, dynamical, intuitive, and quantitative evaluation can be obtained for the perfusion differences between the lesion and the surrounding liver parenchyma, which provides more accurate information for qualitative diagnosis of hepatic tumors thus contains great application value in the evaluation of the effects of radiofrequency ablation for hepatic tumors.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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