Title: Relationship between changes in serum cytokine levels after artificial liver therapy and clinical prognosis in patients with liver failure
Abstract: Objective To investigate the relationship between changes in serum cytokine levels at 72 h after artificial liver therapy(plasma exchange,PE) and clinical prognosis in patients with liver failure.Methods Fifty-eight patients with liver failure,who received PE in Department of Infectious Diseases,The No.2 People′s Hospital of Lanzhou from April 2011 to April 2012,were included in the investigation;they were divided into improved group and uncured group according to their treatment outcomes.The serum interleukin(IL)-4,IL-6,IL-10,tumor necrosis factor(TNF)α,and interferon(IFN)γ levels before and 72 h after therapy were measured,and the relationship between the changes in these indices and prognosis was observed.The data were expressed in the form of mean ± standard deviation.The baseline values and values after therapy were compared by paired t-test,and the differences between two groups were determined by the t-test for comparison between groups.Results After PE therapy,67.24% of all patients(39/58) showed an improvement,while 32.75%(19/58) were not cured.At 72 h after therapy,the improved group had significant changes in serum IL-4,IL-6,IL-10,TNFα,and IFNγ levels(t=2.048-5.163,P0.05),and had more decrease in serum IL-4,IL-6,TNFα,and IFNγ and more increase in serum IL-10 level compared with the uncured group.Before therapy,the serum IL-6 and TNFα levels were significantly higher in the uncured group than in the improved group(t=2.024-2.174,P0.05).Conclusion Artificial liver therapy can decrease TNFα,IL-4,IL-6,and IFNγ and increase IL-10 in serum and thus is an effective treatment for liver failure.It seems that IL-6 and TNFα play a more important role than other cytokines in immune injury in patients with liver failure.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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