Title: An Analysis of Pathogenic Bacterial Distribution and Drug Resistance in ICU
Abstract: Objective To study the distribution of the bacterial pathgens and drug resistance features in intensive care units (ICU) in a hospital, to provide evidence for reasonable use of antibiotics. Methods Five hundred and ten samples were cultured, isolated, identified and their drug resistances tested. Results A total of 460 pathogenic strains were isolated from the 510 specimens. Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumonia were the main strains among the 280 isolates (60.9%) which were Gram-negative bacilli; and 128 isolates were Gram-positive cocci(27.8%),all of which were Staphylococcus aureus, coagulase negative Staphylococcus and Enterococcus; and 52 isolates (11.3%) were Fungus. The isolates producing of extended spectrum beta-lactamases (ESBLs) those in Escherichia and Klebsiella pneumoniae were 22.2% and 36.7% respectively; and producing MRSA and MRCNS were 57.7% and 40%. The isolated pathogens showed serious multi-drug resistance. The resistant rates of Pseudomonas, Stenotrophomonas maltophilia and Acinetobcter spp to imipenem were greater than 20%, but not in Escherichia, Klebsiella pneumoniae and Enterobacter cloacae. No resistant of G~+ cocci to vancomycin was found. Conclusions The pathogenic bacterial distribution and antibiotics susceptibility data provide the evidences that we can select antibiotics reasonably to control the infection and minimize the emergence of new drug-resistant bacteria.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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