Title: Impact of Valsartan in combination with Interferon on the chronic hepatitis B patients AT-II,TGF-β_1 and histopathology
Abstract: Objective:To approach the impact of Valsartan in combination with Interferon on the chronic hepatitis B patients AT-Ⅱ,TGF-β1 and histopathology.Methods:The pathology confirmed 50 cases of chronic hepatitis B were randomly divided into treatment group and control group,each group had 25 patients.Both groups used the common standard interferon,treatment group was treated with Valsartan for 80 mg/d,detected the level of AT-Ⅱ and TGF-β1 before treatment and 48 weeks after treatment,reviewed liver histopathology 15 cases and 13 cases of two groups at the end of 24 weeks treatment.Results:After treatment with Valsartan,AT-Ⅱ was higher than that before treatment,and TGF-β1 was lower than that before treatment,the differences were significant(P0.05).Two serum indexes were relevant to the degree of liver fibrosis,similarly there were significant differences(P0.05).The TGF-β1 expression of two groups both had decreased after treatment(P0.05),while the treatment group decreased more significantly(P0.05),the difference was significant;the liver inflammation and fibrosis score of two groups both had improved(P0.05),the difference was significant in the treatment group,and had more significantly fewer adverse reactions(P0.05).Conclusion:Valsartan in combination with Interferon can more effectively improve the performance of patients with histology,and reduce adverse reactions.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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