Title: Expressions of Multidrug Resistance Gene Products in Gastric Cancer Tissues and The Clinical Significance
Abstract: Objective To detect the characteristic of multidrug resistance gene products expressions in gastric cancer tissues,including glutathione-s-transferase π (GST-π),P-glycoprotein (P-gp),topoisomerase Ⅱ (Topo-Ⅱ),thymidylate synthase (TS),and multidrug resistance related protein (MRP),and analyze their clinical significance for the therapy of gastric cancer.Methods SP immunohistochemical stain was used to detect GST-π,P-gp,Topo-Ⅱ,TS and MRP expressions in sample of 48 gastric cancer tissues and 10 normal gastric mucosa.And their corresponding clinical data were comprehensive analyzed.Results The expressions of GST-π,P-gp,Topo-Ⅱ,TS and MRP had notable differences between the gastric cancer tissues and normal gastric mucosa (GST-π:P0.01;P-gp:P0.01;Topo-Ⅱ:P0.01;TS:P0.05;MRP:P0.05).Positive expression rates of GST-π,P-gp,Topo-Ⅱ,TS and MRP in gastric cancer tissues were 72.9% (35/48),56.3% (27/48),83.3% (40/48),41.7% (20/48) and 39.6% (19/48),and positive expression rates of them in normal gastric mucosa were 10.0% (1/10),0 (0/10),0 (0/10),0 (0/10) and 0 (0/10) corresponding.Their positive expression rates were closely relevant to the degree of differentiation (P0.01),but not to the patients' sex,age,tumour site,size of tumour,invasive depth and lymph node metastasis (P0.05).Conclusions The expressions of GST-π,P-gp,Topo-Ⅱ,TS and MRP in gastric cancer tissues exist obvious heterogeneity.Their overexpression underlie the multidrug resistance of gastric cancer.The joint detection of GST-π,P-gp,Topo-Ⅱ,TS and MRP can be looked as an important symbol for guiding its chemotherapy.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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