Title: Effect of anemia on chemotherapy multidrug resistance in postoperative of gastric cancer
Abstract: Object This study was designed to investgate the expression of P-glycoprotein(P-gp), topoisomerase-Ⅱ(TOPO-Ⅱ),glutathione-S-transferase-π(GST-π) and hypoxia-inducible factor-1α(HIF-1α) in gastric cancer and the effect and possible mechanism of anemia on chemotherapy multidrug resistance in postoperative of gastric cancer. Methods 56 cases of tissue samples of gastric cancer and 20 cases of pericarcinoma normal tissue samples were examined for expression of P-gp、TOPO-Ⅱ、GST-π and HIF-1αby immunohistochemistry. Results ①The expression levels of P-gp、GST-π and HIF-1α in gastric cancer were significantly higher than pericarcinoma normal tissues, however, the expression level of TOPO-Ⅱ in gastric cancer was significantly lower than pericarcinoma normal tissues.②The expression levels of P-gp、GST-π were significantly different in histological types, the expression level of HIF-1α was significantly different in depth of invasion or with and without lymph nodes metastasis. There was no correlation between the expression of them and sexual or age.③In gastric cancer, the expression levels of P-gp、GST-πand HIF-1α were positive correlation with Hb concentration, the TOPO-Ⅱ was negative correlation with Hb, evenmore, the expression level of HIF-1α was positive correlation with the P-gp. Conclusion The chemotherapy multidrug resistance in postoperative of gastric cancer is positive correlation with anemia degree, HIF-1α maybe one of the inducible factors which lead anemia to chemotherapy multidrug resistance in postoperative of gastric cancer.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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