Title: The short-term efficacy and safety of intensive statin therapy in acute coronary syndrome after percutaneous coronary intervention
Abstract: Objective This study was designed to evaluate the short-term effect and safety of 80 mg/d atorvastatin treating on ACS patients with interventional therapy in China. Methods From August 2002 to March 2014,1746 ACS patients accepting 80mg/d atorvastatin treatment were enrolled from three province hospital. All patients were divided into three groups, 886 patients in group A with 80mg/d atorvastatin treating for 4 weeks, 562 patients in group B with 80mg/d atorvastatin treating for 8 weeks, and 298 patients in group C with 80mg/d atorvastatin treating for 12 weeks after discharge. Blood lipid level, hepatic function, renal function and creatine kinase level were tested on 4th, 8th, 12 th week. Results The percentage of patients reacting lipid levels was 85.0% in group A, 86.1% in group B, 94.0% in group C and 86.9% in total. The rate of ALT/AST exceed two times of normal upper level in group A was 1.6%, in group B was 1.8% and in group C was 1.0%.The symptom of joint and muscle pain in group A was 6.3%, group B was 1.4%, group C was 2.7%.The elevation of creatine kinase in group A was 0.8%, in group B was 0.5%, and 0% in group C. The symptom of abdomen discomfort in group A was 2.3%, group B was 2.5% and group C was 4.0%. The complaint of other symptoms was 3.2% in group A, 2.1% in group B, 1.7% in group C. Conclusions Accepting 80 mg/d atorvastatin treating for ACS patients with interventional therapy is effective and safe in short term.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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