Title: Evaluation on Therapeutic Effect of Different Doses of Atorvastatin on Elderly Acute Coronary Syndrome
Abstract: Objective To explore the clinical efficacy of different doses of atorvastatin in treatment of elderly acute coronary syndrome(ACS).Methods Eighty-six patients with ACS were randomly divided into low-dose atorvastatin group and high-dose atorvastatin group(each n=43).All patients received routine treatment,in addition,low-dose group was orally administered with 10 mg/d atorvastatin and high-dose group administered with 20 mg/d atorvastatin for 1 year.The total cholesterol(TC),triacylglycerol(TG),low-density lipoprotein-cholesterol(LDL-C) and high density lipoprotein-cholesterol(HDL-C) before treatment,2 weeks,3 months,6 months and 12 months after treatment were determined,and the cardiovascular events within 1 year and adverse drug reactions(ADRs) were observed.Results Two weeks,3 months,6 months and 12 months after treatment,TC and LDL-C of the two groups were significantly decreased than those before treatment(P0.05 or P0.01).3 months,6 months and 12 months after treatment,TG of the two groups was significantly decreased than that before treatment(P0.05 or P0.01).12 months after treatment,HDL-C of the two groups was significantly decreased than that before treatment(P0.05).2 weeks,3 months,6 months and 12 months after treatment,TC and LDL-C of high-dose group were statistically decreased than those of low-dose group(P0.05).3 months,6 months and 12 months after treatment,TG of high-dose group was statistically decreased than that of low-dose group(P0.05).12 months after treatment,HDL-C of high-dose group was statistically decreased than that of low-dose group(P0.05).The incidence rates of angina,recurrent myocardial infarction and sudden cardiac death of high-dose group were significantly lower than those of low-dose group(P0.05 or P0.01).No statistically significant difference was found in the incidence rate of ADRs between the two groups(P0.05).Conclusions The dosage of atorvastatin 20 mg/d has a better effect in reducing blood lipids,with lower incidence of cardiovascular events and better treatment tolerance for patients.It is worthy of being extensively applied in clinical practice.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot