Title: The expression and prognostic significance of TK1 and Ki-67 in non-small cell lung cancer
Abstract: Objective:To investigate the expressions of thymidine kinase 1(TK1) and Ki-67 in non-small cell lung cancer(NSCLC)and their prognostic value in NSCLC.Methods:The tissue microarrays which contain 202 NSCLC cases and 63 normal lung cases were constructed.The expressions of TK1 and Ki-67 were detected in these tissues by immunohistochemistry method.The relationship between expression levels of two makers and the clinicopathological and survival parameters of NSCLC were evaluated.Results:The positive expression rates of TK1(60.89%)and Ki-67(55.45%)in the NSCLC tissues were significantly higher than those in normal tissue group(P 0.000 1,P 0.000 5).The Spearman correlation analysis showed that the expression of TK1 were positively correlated with Ki-67 expression(r = 0.518,P 0.001).In the group of NSCLC,both TK1 and Ki-67 expression were significant correlated with tumor grade and TNM stage.Kaplan-Meier survival analysis indicated that the survival rate was markedly lower in patients with high expression level of two markers than those with low expression level(P 0.05);Multivariate analysis using Cox regression model identified that TNM stage and TK1 expression were independent prognostic factors of NSCLC(P 0.05).Conclusion:The expression of TK1 was significantly correlated with tumor grade and TNM stage.TK1 might be employed to evaluate the prognosis of NSCLC patients.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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