Title: The Clinical Value of Detecting CRP in the Serum of Patients with Hepatic Cirrhosis and Liver Cancer
Abstract: Objective:To investigate the clinical application value of detecting serum c-reative protein(CRP) in patients with hepatic cirrhosis and liver cancer.Methods:CRP in the serum of 52 patients with hepatic cirrhosis,30 patients with liver cancer and 30 from the normal control were detected by nephelometry,alpha-fetoprotein(AFP) concentration was detected by radio-immunoassay,and the results of the two indicators were compared.Results:High positive rate of CRP level was observed in all disease groups as compared with that of the control group(P0.001,P0.05),and CRP level of liver cancer group was higher than that of the hepatic cirrhosis group and hepatic cirrhosis decompensation group was higher than that of hepatic cirrhosis compensation group.The larger the difference was,the worse the prognosis was.If CRP or AFP in the serum was detected alone,the sensitivity of diagnosing liver cancer was 86.7%and 80.0% respectively,the specificity was 65.8% and 78.0%.With CRP and AFP at least one positive as judgement standard,the sensitivity went up to 96.7%.Conclusion:Detecting the concent of serum CRP of patients with hepaticcirrhosis and liver cancer is helpful to discover and understand the inflammatory activity in the liver and the impared condition of hepatic cells,and provide important reference on clinical diagnosis and therapy.Detecting serum CRP alone is not an ideal index to diagnose liver cancer,but serum CRP and AFP detected together has supplementary effect on diagnosing liver cancer.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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