Title: The value of serum acute phase proteins in early diagnosis of hepatic cirrhosis complicated with infection
Abstract: Objective:To investigate the value of serum acute phase proteins in early diagnosis of hepatic cirrhosis complicated with infection.Methods:Fiftyone patients with hepatic cirrhosis,of whom 25 complicated with infection,were studied.Serum levels of Creactive protein (CRP),α 1acid glycoprotein(AAG),haptoglobin(HPT) and ceruloplasmin (CER) were measured on the second day of admission.All parameters were measured again in 14 patients with hepatic cirrhosis complicated with infection when the infection was under control.Results:Compared with control group,CRP,AAG,HPT were significantly higher in infection group.CRP was significantly decreased after infection was under control,but no significant changes was noted in AAG,HPT,CER.Our study showed that CRP had a sensitivity of 88 00% and specificity of 76 92% in predicting infection if highest range of normal CRP was set to 8 mg/L.Taking account of the higher CRP in hepatic cirrhosis than in those of nonhepatic cirrhosis group,if the highest range of normal CRP was set to 16 mg/L ,which was the mean level in cirrhosis group without infection,the specificity was 92 31%. Conclusions: CRP,AAG and HPT are useful in early diagnosis of hepatic cirrhosis complicated with infection and CRP is more valuable.CRP is also useful in predicting the therapeutic effects.The level of significance of CRP should be set to 16 mg/L to insure the specificity of diagnosis.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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