Title: Comparative study of dissolution on five active components of Fufang Danshen tablets
Abstract: OBJECTIVE To study the dissolution characteristics of five active components of Fufang Danshen tablets in vitro.METHODS The different dissolution solvents and the dissolution rates in vitro of five kinds of active components of Fufang Danshen tablets were investigated.The contents of active components were determined by HPLC.The accumulative dissolution percentages were calculated,and the resemblance of release curves were compared by similarity factors(f2).RESULTS Compared with danshensu,the similarity factors of protocatechualdehyde,notoginsenoside R1,salvianolic acid B,tanshinoneⅡA were 60,61,73 and 17 in 0.5% SDS solution,respectively.The similarity factors of protocatechualdehyde,notoginsenoside R1,salvianolic acid B were 70,40 and 36 in 0.1 mol·L-1 HCl solution,respectively.CONCLUSION The dissolution of active components of Fufang Danshen tablets do not have the same characteristics of synchronous dissolution in 0.5% SDS solution and in 0.1 mol·L-1 HCl solution.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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