Title: An Experimental Study on the Long-term Toxic Effects of Yinlongxian Capsule on Rats
Abstract: Objective:To study the long-term toxic effects of Yinlongxian capsule in rats for the future clinical use of the capsule.Methods:Eighty Wistar rats were randomly divided into 4 groups: control group and the other groups treated with Yinlongxian capsules at different dosages(1.2,0.6 and 0.3 g/kg respectively)for 6 months and the rats in each group were observed for two more weeks after the stop of the medication.During the experimental period,the general status was mornitored and the body weight of the rats was measured each weekend. The blood cells and various biochemical indexes of the blood and the histological changes in 14 major organs of the rats were determined and observed,respectively.Results: In the groups treated with Yinlongxian capsules,the growth rate and liver indexes of the rats were slightly decreased compared with that of control group.No significant changes in the other blood or organ indexes were founded.Additionally,mild diarrhea was obsereved in some of the rats in the group treated with high dosage of Yinlongxian capsule.Conclusions:Yinlongxian capsule should be safe in its clinical use at the recommended dosage.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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