Title: A Study on Long-Term Toxicity of Lianju Ganmao Capsule
Abstract: Objective: To observe long-term toxicity of Lianju Ganmao Capsule,so as to provide toxicological basis for clinical medication.Methods: Eighty-eight Wistar rats were randomly divided into 4 groups(22 in each).Groups H,M,L were orally given high,moderate,or low dosages(2.5,1.25,and 0.625 g/kg) of Lianju Ganmao Capsule respectively,and control group(group C) were given distilled water instead.The experiment was carried out for 13 consecutive weeks.General conditions,body weight and food intake of rats were observed.Haematological and biochemistry parameters,organ coefficient and histomorphological changes were determined in 13 weeks of the experiment and in 2 weeks after drug withdrawal.Results: All the indexes mentioned above were normal in groups H,M,and L during and after the experiment.There was no significant difference between experimental groups and control group.Conclusion: Lianju Ganmao Capsule has no immediate or delayed toxicity in long-term administration on rats when the dosage is in clinical range,and is safe for use.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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