Title: Expression of MDM2 protein in lung cancer tissues
Abstract: OBJECTIVE:To detect the expression of MDM2(murine double minute 2) in lung cancer tissues and cancer-related tissues.METHODS:Western blot was used to detect the expression of MDM2 in 31 lung cancer tissues and peri-cancer tissues.RESULTS: The expression of MDM2 protein (38 123.5±11 153.0) in lung cancer tissues was significantly higher than that in peri-cancer tissues (29 037.0±14 267.4), the higher rate was 77.4%(24/31).Seventeen cases (77.3%) had the overexpression of MDM2 protein in 22 lung squamous cancer tissues, all the 7 tissues of lung adenocarcinoma had the overexpression of MDM2 protein,but 1 tissue with small cell lung cancer and 1 tissue of the big-cell lung cancer had the low expression of MDM2 protein.CONCLUSION: MDM2 plays an important role in the oncogenesis of lung cancer.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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Cited By Count: 1
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