Title: Study on relationship between protein enpression of mismatch repair gene hMSH2 and lung cancer
Abstract: Objective To assess the association between the protein expression of mismatch repair gene hMSH2 and the carcinogenesis of lung cancer. Methods Expression of hMSH2 was detected using immunohistochemistry in 43 lung cancer tissues and 45 bronchietatic tissues as controls.Results The positive expression rate of hMSH2 protein was 88.4%(38/43) in cancer tissues, while that was only 35.9%(16/45) in control tissues.At the same time, cancer tissues showed stronger expression than control tissues and the hMSH2 protein expression in low grade tumor was stronger than that in high grade tissues. All 11 normal tissues showed negative expression of hMSH2 protein. Conclusion The expression of hMSH2 is related to lung cancer and abnormal expression may play a role in pathogenesis of lung cancer.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot