Title: A study on the relationship between the expression of protein kinase C βII and apoptosis in patients with non-small cell lung cancer
Abstract: Objective To investigate the role of protein kinase C βⅡ (PKC βⅡ) expression and apoptosis in the oncogenesis and development of non small cell lung cancer. Methods The expression of PKC βⅡ and apoptosis were detected in 119 human non small cell lung cancer tissues and paracancerous lung tissues by TUNEL and LSAB, and 32 benign pulmonary disease tissues as control. Results The expression of PKC βⅡ (85.39%) in lung cancer tissues was significantly higher than that in paracancerous lung tissues and benign pulmonary disease tissues (65.69% and 53.22%) ( P 0.05), and the PKC βⅡ expression in paracancerous samples was also remarkably higher than that in benign pulmonary disease samples ( P 0.05). The apoptotic index (AI) (5.27%) in lung cancer tissue was significantly lower than that in the benign lung lesion tissue (15.84%) ( P 0.05). No significant relationship was observed between the expression of PKC βⅡ in lung cancer tissue and clinical physiopathological characteristics ( P 0.05). The AI in the lung cancer tissues was closely related to the stages of the cancer, size of primary tumor and lymph node metastasis ( P 0.05), but not to the histological classification, cell differentiation and location of the tumor, and sex and age of the patient with lung cancer ( P 0.05). A highly significant negative correlation was observed between PKC βⅡ expression and AI in the lung cancer group ( P 0.01). Conclusion The abnormal activation of PKC βⅡ and the suppression of apoptosis may play important roles in the oncogenesis and development of non small cell lung cancer. The overproliferation of cells and suppression of apoptosis transducted by PKC βⅡ may be one of the important mechanisms of the oncogenesis and development of non small cell lung cancer.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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