Title: Relationship between expression of CCR5 and c-erbB-2 in breast cancer and lymph nodes metastasis
Abstract: OBJECTIVE: To detect the expression of CCR5 and c-erbB-2 in breast cancer tissues,and analyze the relationship between CCR5 and c-erbB-2 and lymph nodes metastasis.METHODS: Expressions of CCR5 and c-erbB-2 in 72 breast cancer tissues were detected with immunohistochemistry SP.RESULTS: CCR5 was detected in 61 of 72 cases;the CCR5 positive incidence was 84.7%,in which there were 46 cases with positive lymphatic metastasis.There was positive correction between CCR5 and lymphnode metastasis(χ2=4.982,P=0.026),c-erbB-2 over-expressions(χ2=4.583,P0.05).CONCLUSION: CCR5 may be a new biological marker to suggest the development and prognosis of breast cancer.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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