Title: Synthsis of trehalosyl methyl fumarate and its inhibiting activity
Abstract: Trehalosyl methyl fumarate(TMF) was synthesized in three steps: 1) Take methanol and maleic anhydride(mole ratio 1∶1) as raw material,3% anhydrous AlCl3 and 4% sodium bisulfate as isomerization catalyst for esterification reaction at 60 ℃ for 0.5 h,followed by isomerization at 80 ℃ for 2 h.The end product of this step is monomethyl fumarate(MMF).2) Take MMF and thionyl chloride(mole ratio 1.0∶2.5) as raw material for reaction at 90 ℃ for 1 h.This step produces monomethyl fumarate chloride(MMFC).3) MMFC and trehalose is mixed with mole ratio 4.0∶1.0 and reaction at 40 ℃ for 3 h,with methylene chloride as dispersing agent,10% anhydrous potassium carbonate and 10% Bu4NBr(w%MMFC) as phase transfer catalyst.End product TMF is obtained in this step with 69.24% receiving rate.The results of inhibiting activity test indicate that TMF has very good inhibiting activity for hybrid fungus.Its inhibiting activity is better than MMF and comparable to that of benzoic acid.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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