Title: Clinical Significance of Expression of MDM2 P53 Protein and Apoptosis in Bladdercancer
Abstract: Objective To investigate the expression of MDM2 Pgp protein and apoptosis and its significance in bladder cancers.Methods Apoptosis Index(AI) was assessed with TUNEL technique,and immunohistochemical stainings of MDM2 and Pgp were performed in 83 cases of the carcinomas and 11 “normal” bladder mncosa.Results The positive expression rate of P53 gene was 50.6% and MDM2 was 59.03%,and AI=1.433 5±0.386 3.The level of MDM2 was negative correlated with the tumor pathological grade and clinical stage(R=-0.263,P=0.016及R=-0.388,P=0.001);The level of P53 was positive correlated with the tumor pathological grade(R=0.492,P=0.001);No correlated was found between MDM2 and P53 gene;The level of AI was negative correlated with MDM2(R=-0.226,P=0.042);The level of AI was positive correlated with the tumor pathological grade and clinical stage (R=0.642,P=0.000;R=0.455,P=0.000);The level of AI was no correlated with P53.AI and the expression of P53 and MDM2 were related to 5-year survival rate.Conclusion By exerting the tumor pathological grade and clinical stage and detecting P53 MDM2 genes expressions,the prognosis of bladder cancer can be decided.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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