Title: The prognostic significance of bcl-2 and p53 expression in bladder cancer
Abstract: Objective: To detect the prognosis value of the expression of p53 and bcl-2 protein, as well as then relationship of these two proteins as determined by immunohistochemistry in bladder cancer. Methods: Tumor samplesb from 131 patients with bladder cancer were assessed immunohistoc hemically usi ng the clone DO - 7 and 124 monoclonal antibody and labeled streptavidin biotin staining for p53 and bcl-2 protein. Results : 65. 6% tumors were positive for p53 and 26. 7% for bcl-2, respectively. A statistically significant differences of p53 staining were observed between grade 3 and grade 1-2 (P = 0. 0012), invasive and supefficial stage (P 0. 000l ), as well as overall survival (P =0. 007). while p53 positive was not independent predictor for overall survival by multivariate analysis. There was no correlation of bcl-2 staining with the histological grade, clinical stage or outcome. Conclusion: Immunostaining of p53 and bcl-2 has no important value for prognosis in bladder cancer.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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