Abstract: The gastric wall is composed of three layers: the mucosa, the muscularis mucosae, and the serosa. The gastric mucosa is lined by a single layer of mucussecreting columnar epithelium punctuated by pits where the gastric glands are situated. The stomach can be divided histologically into three areas according to the predominant gland type: cardiac, fundus or oxyntic, and antral. The cardiac region is the area just distal to the gastroesophageal junction; it contains mainly mucus-secreting glands and endocrine cells. The fundus/oxyntic region extends from the cardia to the dome-shaped fundus and the body of the stomach to the level of the incisura angularis. It contains parietal cells that secrete HCL and intrinsic factor, chief cells that secrete pepsinogen, G cells thatsecrete gastrin,and enterochromaffin cellsthat secrete histamine and serotonin. The antral/pyloric region is located distal to the incisura angularis, and contains D cells that secrete somatostatin, G cells, and enterochromaffin cells.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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