Title: Chronic toxicity of Chuangouqufeng Vinum in rats
Abstract: OBJECTIVE To observe the chronic toxicity of Chuangouqufeng Vinum in rats.METHODS Rats of 2 experimental groups were administrated Chuangouqufeng Vinum at dose of 4000 and 2000mg·kg-1·d-1,respectively,6 days per week for 3 months.Rats of positive control group and alcohol control group were given distilled water and 15% alcohol with the same volume respectively.Growth of rats was observed.Indexes of hematology and blood biochemistry were measured.Major organ coefficients were measured and the major organs were examined by the pathology.All these tests were carried out three months after administration and one month after stopping administration.RESULTS The weights,the indexes of hematology and the organ coefficient were normal.The change of blood biochemistry and the pathological examination of the liver in the treatment groups had no significant difference by comparing with the alcohol control group.CONCLUSION Chuangouqufeng Vinum has no significant toxicity for long term administration to rats except for the toxicity of alcohol.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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