Title: Phloroglucinol and flavonioid constituents of hypericum acmosepaium
Abstract: Cytotoxicity screening of extracts of Hypericum acmosepaium N.Robson were carried out by L_(1210) cell and KB cell.Isolation of chemical constituents as carried out from the effective parts of H.acmosepaium by column chromatography.The chemical structures as identified by physical and chemical constants and spectral data analysis.Six compounds have been isolated and their structures have been established as paglucinol (1);5-hydroxy-6-isobutyryl-2,2,8-trimethyl-8-(3'-methylbut-2-enyl)-2,8-dihydro-1-benzopyran-7-one (2);5-hydroxy-6-propionyl-2,2,8- trimethyl-8-(3-methylbut-2-enyl)-2,8-dihydro-1-benzopyran-7-one (3);7,8-(2,2-dimethylpyrano)-5,3',4'-trihydroxy-3-methoxylflavone (4);quercetin (5) andⅠ3,Ⅱ8-biapigenin (6).In addition,the fractions of dichloromethane extraction,ethyl acetate extraction,compounds 2 and 5 possess cytotoxic activities.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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