Title: Xanthone constituents of Hypericum subsessile
Abstract: Cytotoxicity screening of the extracts of Hypericum subsessile N.Robson as carried out by L_(1210) cells.Isolation of chemical constituents as carried out from the effective parts of H.subsessile by column chromatography. The chemical structures were identified by physico-chemical properties and spectral data.Six xanthone constituents have been isolated and elucidated as 2,3- dimethoxyxanthone (1),1,3- dihydroxy-5,6- dimethoxyxanthone (2),toxyloxanthone B (3),kielcorin (4),candensin D(Hypericorin) (5) and subalatin(6). Compounds 1~6 were obtained from H.subsessile for the first time.In addition,CHCl_3 and EtOAc fractions possess cytotoxic activities and the IC_(50) are 8.8 and 14.6?μg/mL for L_(1210) cells,respectively.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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