Title: Role and Expression of uPAR in Invasion and Metastasis of Naspharyngeal Carcinoma(NPC)
Abstract: Objective To investigate the expression and role of urokinase-type plasminogen activator receptor (uPAR ) in the invasion and metastasis of NPC.Methods Expression of uPAR gene in 55 surgically resected NPC tissuses were detected by RT-PCR assay and immunohistochemical staining.Then the relationship between uPAR expression and NPC clinical pathological features was explored.Results There were uPAR gene and protein expression in NPC tissues.uPAR protein was located in tumor cell cytoplasm and / or cell membrance. uPAR expression was higher in cancerous tissues with lymphatic metastasis than that without lymphatic metastasis (P0.01). uPAR expression was higher in TNM Ⅲ~Ⅳstage of cancerous tissues than that in Ⅰ~Ⅱstages (P0.01).Conclusion Expression of uPAR is correlated to invasion and metastasis of NPC.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot