Title: Modulation and implications in pathogenesis of interferon gamma receptor 1 in patients with chronic hepatitis B
Abstract: Objective To study the possible differences in the interferon gamma receptor (IFN-y R1) response among a variety of clinical types in patients with chronic hepatitis B (CHB) and implications in pathogenesis. Methods The serum level of IFN-y and the expression level of IFN-y Rl in peripheral leucocytes, from 53 CHB patients, were examined by ELISA and flow cytometry respectively, which were compared with the baseline levels of 15 healthy controls and were performed correlation analysis with alanine aminotransferase (ALT), total bilirubin (TBil) in serum and morphological change in hepatic tissues. Results The results showed that the level of IFN-y Rl (28.89% ?11.77%) expressed on the membranes of lymphocytes in CHB patients, which correlated with liver inflammation (r=0.621, P0.0\) and serum TBil level (r=0.575, P0.01), was much higher than that (9.23% + 1.30%) of the healthy controls (Z=3.988, P0.05), and no obvious difference on the membranes of leucocytes. The serum levels of IFN-y in patients with cirrhosis and severe hepatitis were higher than those of healthy controls . And the two was no difference from each other, but the standard deviation in each group was relatively large. Conclusions These findings suggest that the IFN-y signal transduction pathway is modulated through up-regulating the expression of IFN-y Rl on the membranes of lymphoctes, which takes part in the immuno-pathogenesis in CHB patients.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot