Publication Information

{'id': 'https://openalex.org/W2375623848', 'doi': None, 'title': 'Effect of Flavonols on Caspase-3,Bcl-2 and Bax Expression in Cardiomyocytes Apoptosis', 'display_name': 'Effect of Flavonols on Caspase-3,Bcl-2 and Bax Expression in Cardiomyocytes Apoptosis', 'publication_year': 2007, 'publication_date': '2007-01-01', 'ids': {'openalex': 'https://openalex.org/W2375623848', 'mag': '2375623848'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://en.cnki.com.cn/Article_en/CJFDTotal-ZGYX200710010.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764966987', 'display_name': 'Zhōnghuá yàoxué zázhì', 'issn_l': '1016-1015', 'issn': ['1016-1015'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4323237738', 'host_organization_name': 'Pharmaceutical Society of the Republic of China', 'host_organization_lineage': ['https://openalex.org/P4323237738'], 'host_organization_lineage_names': ['Pharmaceutical Society of the Republic of China'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020839094', 'display_name': 'Yang Bao-fengc', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Yang Bao-fengc', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5020839094'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.826211, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 73, 'max': 76}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13776', 'display_name': 'Phytochemical and Pharmacological Studies', 'score': 0.5634, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13776', 'display_name': 'Phytochemical and Pharmacological Studies', 'score': 0.5634, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/myricetin', 'display_name': 'Myricetin', 'score': 0.8532374}, {'id': 'https://openalex.org/keywords/flavonols', 'display_name': 'Flavonols', 'score': 0.8305918}, {'id': 'https://openalex.org/keywords/mtt-assay', 'display_name': 'MTT assay', 'score': 0.6006192}, {'id': 'https://openalex.org/keywords/morin', 'display_name': 'Morin', 'score': 0.59987867}], 'concepts': [{'id': 'https://openalex.org/C2778173338', 'wikidata': 'https://www.wikidata.org/wiki/Q951449', 'display_name': 'Myricetin', 'level': 5, 'score': 0.8532374}, {'id': 'https://openalex.org/C2779106036', 'wikidata': 'https://www.wikidata.org/wiki/Q2629666', 'display_name': 'Flavonols', 'level': 4, 'score': 0.8305918}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.8303499}, {'id': 'https://openalex.org/C196795494', 'wikidata': 'https://www.wikidata.org/wiki/Q1624817', 'display_name': 'TUNEL assay', 'level': 3, 'score': 0.8117118}, {'id': 'https://openalex.org/C2775963812', 'wikidata': 'https://www.wikidata.org/wiki/Q407857', 'display_name': 'Rutin', 'level': 3, 'score': 0.7917907}, {'id': 'https://openalex.org/C2781263971', 'wikidata': 'https://www.wikidata.org/wiki/Q409478', 'display_name': 'Quercetin', 'level': 3, 'score': 0.7559528}, {'id': 'https://openalex.org/C2780783641', 'wikidata': 'https://www.wikidata.org/wiki/Q738686', 'display_name': 'MTT assay', 'level': 3, 'score': 0.6006192}, {'id': 'https://openalex.org/C2779968248', 'wikidata': 'https://www.wikidata.org/wiki/Q418224', 'display_name': 'Morin', 'level': 2, 'score': 0.59987867}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.53455484}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5327112}, {'id': 'https://openalex.org/C553184892', 'wikidata': 'https://www.wikidata.org/wiki/Q1141429', 'display_name': 'Flow cytometry', 'level': 2, 'score': 0.46388158}, {'id': 'https://openalex.org/C12519072', 'wikidata': 'https://www.wikidata.org/wiki/Q14914370', 'display_name': 'Caspase 3', 'level': 4, 'score': 0.42413944}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.38151118}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.3309506}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.28861022}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.22975776}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.21052718}, {'id': 'https://openalex.org/C2777810353', 'wikidata': 'https://www.wikidata.org/wiki/Q393336', 'display_name': 'Kaempferol', 'level': 4, 'score': 0.1396203}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.1263547}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0649828}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://en.cnki.com.cn/Article_en/CJFDTotal-ZGYX200710010.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764966987', 'display_name': 'Zhōnghuá yàoxué zázhì', 'issn_l': '1016-1015', 'issn': ['1016-1015'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4323237738', 'host_organization_name': 'Pharmaceutical Society of the Republic of China', 'host_organization_lineage': ['https://openalex.org/P4323237738'], 'host_organization_lineage_names': ['Pharmaceutical Society of the Republic of China'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.66}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3141371042', 'https://openalex.org/W3126380593', 'https://openalex.org/W2982456222', 'https://openalex.org/W2982420234', 'https://openalex.org/W2938744526', 'https://openalex.org/W2923753633', 'https://openalex.org/W2890201889', 'https://openalex.org/W2739190473', 'https://openalex.org/W2588824449', 'https://openalex.org/W2491740661', 'https://openalex.org/W2473212350', 'https://openalex.org/W2416325980', 'https://openalex.org/W2390805229', 'https://openalex.org/W2381993400', 'https://openalex.org/W2380841852', 'https://openalex.org/W2375595138', 'https://openalex.org/W2368292008', 'https://openalex.org/W2350333826', 'https://openalex.org/W2170827555', 'https://openalex.org/W2074046054'], 'abstract_inverted_index': {'OBJECTIVE': [0], 'To': [1], 'study': [2], 'the': [3, 89, 118, 123, 145, 150, 154], 'protective': [4, 129, 135], 'effect': [5], 'of': [6, 11, 53, 65, 91, 112, 120, 125, 133, 147, 152, 156], 'flavonols(quercetin,myricetin,morin': [7], 'and': [8, 93, 114], 'rutin)on': [9], 'apoptosis': [10, 110, 132], 'neonatal': [12, 19], 'rat': [13, 20, 55], 'cardiomyocytes': [14, 21, 56], 'induced': [15, 58], 'by': [16, 59, 70, 76, 104], 'H2O2.METHODS': [17], 'The': [18], 'were': [22, 38, 57, 68, 116], 'cultured': [23, 49], 'for': [24, 50, 88], '48': [25], 'h': [26], 'in': [27], 'vitro,H2O2(100': [28], 'μmol·L-1)was': [29], 'used': [30, 87], 'to': [31, 140, 143], 'build': [32], 'an': [33], 'oxidative': [34], 'stress-induced': [35], 'injury': [36], 'model.Cardiomyocytes': [37], 'randomly': [39], 'divided': [40], 'into': [41], 'several': [42], 'groups:normal,model,cultured': [43], 'with': [44, 107], 'different': [45, 66], 'flavonols(30': [46], 'μmol·L-1).After': [47], 'being': [48], '1': [51], 'h,apoptosis': [52], 'Neonatal': [54], 'H2O2': [60], 'except': [61], 'normal': [62], 'group.The': [63], 'cytotoxicity': [64, 100], 'flavonols': [67], 'determined': [69, 75], 'MTT': [71, 105], 'assay.Apoptosis': [72], 'rates': [73, 111], 'was': [74, 86], 'terminal': [77], 'deoxynucleotidyl': [78], 'transferase-mediated': [79], 'dUTP': [80], 'nick': [81], 'end': [82], 'labelling(TUNEL)and': [83], 'flow': [84], 'cytometry(FCM).Immunohistochemistry': [85], 'detection': [90], 'caspase-3,Bcl-2': [92], 'Bax': [94], 'protein.RESULTS': [95], 'Each': [96], 'flavonol': [97], 'showed': [98], 'no': [99], 'at': [101], '5,30': [102], 'μmol·L-1': [103], 'assay.Compared': [106], 'model': [108], 'group,the': [109], 'quercetin,myricetin': [113], 'morin': [115], 'decreased,increased': [117], 'ratio': [119], 'Bcl-2/Bax,and': [121], 'inhibited': [122], 'activiation': [124], 'caspase-3.CONCLUSION': [126], 'Quercetin,myricetin,morin': [127], 'have': [128], 'effects': [130], 'on': [131], 'cardiomyocytes.The': [134], 'mechanism': [136], 'could': [137], 'be': [138], 'related': [139], 'its': [141], 'ability': [142], 'inhibit': [144], 'activation': [146], 'caspase-3': [148], 'protein,up-regulate': [149], 'expression': [151, 155], 'Bcl-2,down-regulate': [153], 'Bax,quercetin': [157], 'siows': [158], 'a': [159], 'strong': [160], 'anti-apoptotic': [161], 'activity.': [162]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2375623848', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-30T12:31:12.393803', 'created_date': '2016-06-24'}