Title: Value of heart-type fatty acid-binding protein to the early diagnosis of acute myocardial infarction
Abstract:Objective To investigate the value of heart-type fatty acid-binding protein(H-FABP) to the early diagnosis of acute myocardial infarction.Methods A total of 83 patients were suspected acute myocardial...Objective To investigate the value of heart-type fatty acid-binding protein(H-FABP) to the early diagnosis of acute myocardial infarction.Methods A total of 83 patients were suspected acute myocardial infarction at admission in 6 hours after onset of acute chest pain.They were randomly divided into AMI group(n=32) and non-AMI group(n=51) including 33 patients with unstable angina pectoris(UAP group) and 18 patients with non-cardiogenic chest pain(NCCP group).Another 40 healthy volunteers were as controls(control group).The plasma level of H-FABP was measured with ELISA,and compared with the traditional cardiac markers.Results The H-FABP level was significantly higher in AMI group than that in the other three groups(P0.01).ROC curve showed AUC of H-FABP was 0.954(95%CI: 0.912 to 0.997).The optimum cut-off point of H-FABP for diagnosing AMI was 6.65 ng/mL.The sensitivity,specificity,negative prediction value and accuracy of H-FABP for diagnosing AMI in 6 hours were 90.26%,80.39%,93.18% and 84.34% respectively.The sensitivity,negative prediction value and accuracy of H-FABP were significantly higher than those of the traditional cardiac markers as myoglobin,creatine kinase-myocardial band and cardiac troponin I(P0.05).Conclusion H-FABP has better value to diagnosing AMI in the early stage.Read More
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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Cited By Count: 1
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