Title: Reduced oocyte aging improves the outcome of rescue intra-cytoplasmic sperm injection after total fertilization failure
Abstract: Objective To compare the outcome of rescue intra-cytoplasmic sperm injection(ICSI) performed on patients in Group 6 h and Group 22 h after 6 h or 22 h initial in vitro fertilization(IVF).Methods Among 65 failure IVF cycles,rescue ICSI was performed on 6 h and 22 h after initial IVF retrospectively.The data of fertilization and cleavage rates,embryo quality,implantation,and pregnancy rates after rescue ICSI were analyzed and compared between two groups.Results The fertilization rate and cleavage rates in Group 6 h with 77.1% and 97.1% were higher than those in Group 22 h with 47.5% and 68.3% that the difference was significant(P0.05).Clinical pregnancies of Group 6 h was 44.0% including 18 singletons and 4 sets of twins while no clinical pregnancy was in Group 22 h.Conclusion Rescue ICSI after 6 h post-insemination has better fertilization and pregnancy rates compared with rescue ICSI after 22 h when oocytes have become aged.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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