Title: Efficacy of Benserazide and Desipramine on the Improvement of Depressive Symptoms and Quality of Life in Patients with Parkinson's Disease
Abstract: Objective To explore the efficacy of Benserazide and Desipramine on depressive symptoms and the quality of life in patients with Parkinson′s disease(PD). Methods 108 PD patients who had depressive symptoms were recruited from our hospital. All patients were randomized into two groups: treatment group (51 patients) and the control group (57 patients). Participants of treatment group had taken Desipramine and Benserazide,and control group had taken placebo and Benserazide.To evaluate the degree of improvement,depressive symptoms were measured with Montgomery asberg depression rating scale(MADRS) and the quality of life with PDQ-39 at day 14 and 30. Results The two groups have insignificant differences of scores of PDQ-39 and MADRS before and after 14 days treatment(P0.05). But after 30 days treatment, the scores of PDQ-39 and MADRS in treatment group were significantly lower than those of control group(P0.05). Compared with severe depression, Desipramine had a more favorable effects on mild and moderate depression(P0.05). Conclusions Treatment with Desipramine combined with Benserazide can improve the depressive symptoms and the quality of life in patients in a short time, Desipramine had more favorable effects on mild and moderate depression patients.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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