Title: Expression and significance of P-glycoprotein in Cervical Carcinoma
Abstract: Objective:To study the expression and significance of P-glycoprotein(P-gp)in cervical carcinoma.Me-(thods:The) P-gp expression of tissues in 38 cases of cervical carcinoma,16 cases of cervical intraepithelial neoplasm(CIN)and 16 cases of normal cervix was detected by S-P immunohistochemical method.Results:The P-gp expression was found in all tissues mentioned above.The strongly positive staining in cervical carcinoma was higher than that of the normal cervix(P0.05).Conclusion:There is primary multidrug resistance for cervical carcinoma,the positive expression of P-gp is one of the reasons for chemotherapy failure.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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