Title: Expression of CDK8 and Its Significance in Cervical Carcinoma and CIN
Abstract: Objective: To investigate the expression of CDK8 and its significance in development of cervical carcinoma and CIN. Methods: The expression of CDK8 was determined using histochemistry in 40 cervical carcinoma tissues,60 cervical high-grade disease,60 cervical low-grade disease and 20 normal cervical tissues. The expression of Ki-67、P53 in 40 cervical carcinoma tissues was also determined using immunohistochemistry. The relationship among expression of CDK8、Ki-67、P53 was statistically analyzed. Results: CDK8expression increases with disease grade( P0. 05). Through single-factor and multi-factor analysis,positive correlation wass observed between CDK8 expression and lymphoid metastasis( t =6. 587,P0. 05; t =2. 384,P0. 05) 。In cervical carcinoma tissues,P53 expression is positively correlated with CDK8 andKi-67 expression( P0. 05) 。In cervical low-grade disease,there is no significant difference of CDK8 expression between the healing group and the persistent group( P0. 05). While for the cervical high-grade disease,CDK8 expression in the persistent group is higher than that in the healing group( P0. 05) 。Conclusions: There is a positive relationship between expression of CDK8 protein and development of cervical carcinoma. Positive relationship was observed between expression of CDK8、Ki-67、P53 protein in cervical carcinoma. CDK8 may have an important role in predicting the prognosis of cervical high-grade disease.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot