Title: Hemangiopericytoma of central nervous system:a clinicopathological analysis
Abstract:Objective To analyze the clinicopathological features, diagnosis and differential diagnosis of hemangiopericytoma (HPC) of the central nervous system. Methods The clinical manifestations, pathological...Objective To analyze the clinicopathological features, diagnosis and differential diagnosis of hemangiopericytoma (HPC) of the central nervous system. Methods The clinical manifestations, pathological characteristics and differential diagnosis of HPC were analyzed retrospectively by examining the data of 22 cases of HPC studied by imaging, light microscopy, immunohistochemistry and electron microscopy. Results Age of the HPC patients ranged from 18 to 66 (median 48), and ratio of male to female was 1∶1. Of the 22 cases, 16 were WHO gradeⅡ and 6 were WHO grade Ⅲ. Nine cases had been followed-up with a period ranging from 6 months to 6 years, recurrence was seen in 3 cases and metastasis in 1. CT and MRI showed that the tumor was generally single and lobular, with abundant blood supply and flow-void sign. Calcification and dural tail sign were rarely seen. Immunohistochemically, vimentin and CD34 were positive in all the cases, CD99 was positive in 14 (64%), BCL-2 in 9 (41%). EMA was negative or focally positive. Reticular fiber staining displayed every tumor cell was surrounded by reticular fiber. Under electron microscopy, the tumor cells were encapsulatd by basal lamina-like amorphous structure, and there were no apparent intercellular desmosomes and gap junctions. Conclusions HPC is an infrequent tumor of the central nervous system and has a tendency of recurrence and metastasis. It should be differentiated from other tumors of the central nervous system.Read More
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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