Title: Clinicopathologic study of melanocytic lesions in central nervous system
Abstract:Objective To appraise the clinicopathologic feature,diagnosis and differential diagnosis,and treatment and prognosis of melanocytic lesions in central nervous system(CNS).Methods An infant autopsy cas...Objective To appraise the clinicopathologic feature,diagnosis and differential diagnosis,and treatment and prognosis of melanocytic lesions in central nervous system(CNS).Methods An infant autopsy case of neurocutaneous diffuse melanosis,10 cases of meningeal melanocytoma and 2 cases of primary meningeal malignant melanoma were studied by light microscopy,immunohistochemistry and electron microscopy,and literatures were reviewed.Results The full-term male infant autopsy case was seven days old,with several melanocyte nevi in occiput,left face and neck.Melanin deposition was found in leptomeninges of cerebrum,temporal and cerebellum and also in brain parenchyma.Of the ten meningeal melanocytoma patients,six were female and four were male,aged 14-69 years(mean 37 years).Microscopically,the tumor consisted of spindle cells and polygonal cells arranged in patchy and fascicular form.The nuclei were oval with no obvious abnormality.Immunohistochemistry showed that the tumor cells were positive for HMB-45,S-100 and vimentin,but were negative for GFAP,EMA,NSE,Syn and Leu-7.Many melanosomes were found in cytoplast under electron microscope.Primary meningeal malignant melanoma appeared as isolated tumor mass with invasive brim.The tumor cells were pleomorphic with mitoses and necrosis was easy to find.Conclusions The three types of pathological melanocytosis of CNS are rare,and the biological behaviour and prognosis of these three types of lesion were different.Read More
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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