Title: Monitoring and analysis of serum concentration of Phenytoin in 143 Epileptic Patients
Abstract: OBJECTIVE To analyze the monitoring result of serum concentration of phenytoin in patients with epilepsy and provide evidence for rational use of this drug.METHODS HPLC is used to measure the serum concentration of phenytoin.At the same time,observe the clinical efficacy of these 143 epileptic patients and find out the situation of drug combination.RESULTS The serum concentration of phenytoin in lower than 10μg·mL-1,10~20μg·mL-1 and higher than 20μg·mL-1 accounted for36.36%,27.97% and 35.66%.And toxic reaction was accounted for 10.49%.CONCLUSION Monitoring of serum concentration of phenytoin for long term usage patients provide objective evidence for clinician to make individualized therapeutic regimen and play an important role in raising the safety and effectiveness in the treatment of epilepsy.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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