Title: Monitoring of Serum Phenytoin Concentration in 130 Cases and Analysis of the Cases of Intoxication
Abstract: OBJECTIVE: To study the relationship among the dosage, serum concentration and clinical effect of phenytoin
(PHT) in treating epileptic patients .METHODS: 130 steady -- state serum concentrations of PHT were determined by fluores-
cence polarization immunoassay(FPIA) in 70 patients with or without other drugs used in combination .RESULTS: The indi-
vidual difference among the patients who received routine dosage of PHT was very significant. Intoxication occurred ex-
tremely often in patients whose PHT serum concentrations were over 30μg/ml .CONCLUSION: It is necessary to perform TDM
(Therapeutic Drug Monitoring) and individualize the use of PHT,so that the safe and effective use of drug can be ensured.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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