Title: The expression of MCL-1 and its significance in oral squamous cells carcinoma
Abstract: Objective To explore the expression of MCL-1 and its significance in oral squamous cell carcinoma(OSCC). Methods The expression of MCL-1 protein was detected using immunohistochemistry,and the MCL-1 mRNA was assayed by real-time fluorescent quantitative PCR. Results 52 of 84 samples(61.9%)in OSCC tissues were found to over-express MCL-1protein,while 3 of 20 samples(15.0%)in oral normal mucosa tissues were found to over-express MCL-1 protein. Statistical differences(P0.001)existed between these two groups. The expression of MCL-1 mRNA in OSCC was higher than in OSCC adjacent normal tissues(P0.05). Conclusion The high expression of MCL-1 in OSCC has played an important role in the development of OSCC.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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