Title: Effects of ligustrazine injection on nitric oxide(NO) and endothelin 1(ET-1) in cor pulmonale at acute stage cases
Abstract: OBJECTIVE To explore the clinical curative effect of ligustrazine injection on treating cor pulmonale at acute stage and to study the effects of which on nitric oxide(NO) and endothelin 1(ET-1).METHODS60 cor pulmonale at acute stage cases were divided into two groups(30 in each) randomly,which were treated with conventional therapy and Ligustrazine injection associated with conventional therapy respectively.The serum levels of NO and ET-1 were measured before and after treatment.20 healthy persons composed the control group.RESULTSThe serum NO level of the cor pulmonale at acute stage was significantly lower than that of control group(P0.01);While the serum ET-1 level of the cor pulmonale at acute stage was higher than that of control group(P0.01).Moreover,after Ligustrazine injection treatment serum NO level markedly increased(P0.01),while serum ET-1 level decreased (P0.05).CONCLUSIONLigustrazine injection may increase the serum NO level and decrease the serum ET-1 level,accordingly contribute to lower the pulmonary hypertension.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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