Title: Research on relation between methylene tetrahydrofolate reductase(MTHFR) genepolymorphisms,levers of plasma homocysteine(Hcy) and coronary heart disease in the elderly
Abstract: Objective:To observe the association of plasma(Hcy) and polymorphism in 5,10 MTHFR genes coronary heart disease in the elderly.Methods:120 elderly patients with coronary heart disease and 58 controls were studied.The Hcy levels were measured by high performance liquid chromatography fluorescence detection.The polymorphism in MTHFR was determined by a polymerase chain reaction(PCR) assay and subsequent restriction enzyme digestion.Results:The genotype distribution of MTHFR R677 site and the frequency of alleles were significant difference in cerebral infarction group and control group(P all0.05).The frequency of T alleles and the fast Hcy levels were higher in the cerebral infarction group compared with those in the control group(P all0.05).Conclusions:The MTHFR gene mutations can lead to hyperhomocysteinemia increase in the elderly patients with coronary heart disease.The mutations in MTHFR and hyperhomocysteinemia are risk factors for coronary heart disease in elderly.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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